Children at the heart of global surgery: children’s surgery in low- and middle-income countries
Review Article

Children at the heart of global surgery: children’s surgery in low- and middle-income countries

Alizeh Abbas, Lubna Samad

Global Health Directorate, Indus Health Network, Karachi, Pakistan

Contributions: (I) Conception and design: All authors; (II) Administrative support: None; (III) Provision of study materials or patients: None; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Alizeh Abbas. Global Health Directorate, Indus Health Network Office, Woodcraft Building, Plot 3 and 3A, Sector 47, Korangi Creek Road, Karachi, Pakistan. Email: alizeh.abbas@ghd.ihn.org.pk

Abstract: Global child health is incomplete without the inclusion of global children’s surgery. Despite recent advances, many challenges exist in the field of global children’s surgery. Currently, an estimated 1.7 billion children lack access to safe, affordable, and timely surgery and anesthesia care globally. The aim of this review article was to discuss challenges and achievements in the field of global children’s surgery with a focus on workforce capacity, training and education, research, and financing. Almost a half of the population in many low- and middle-income countries (LMICs) is comprised of children under the age of 15. Even then, many LMICs suffer from severe workforce shortages, inadequacy of strong medical schools and children’s surgery training programs, and limited research capacity and funding dedicated to children’s surgery. Specifically, Malawi and Pakistan were reported to have a pediatric surgical workforce density (PSWD) of only 0.17 and 0.4 children’s surgeons per million children, respectively. Unavailability of robust research and educational programs within an individual’s home country has also been seen to motivate students and trainees to pursue specialized children’s surgical training abroad, which further exacerbates the ongoing workforce deficiencies. Recently, the introduction of the Global Initiative for Children’s Surgery has played a pivotal role in advancing the field of children’s surgery, by promoting stronger LMIC representation and inclusion in advocacy, research, and education. In addition, successful international research collaborations, including the GlobalPaedSurg and GlobalSurg; training courses and programs; organizational efforts to improve infrastructure and service delivery, including KidsOR; and inclusion of children’s surgery into the national surgical, obstetrics, and anesthesia plans (NSOAPs) underscore the importance of engaging LMIC colleagues and stakeholders to achieve the seemingly audacious but reasonable goal of making sure that every child has access to safe surgical care.

Keywords: Global surgery; children’s surgery; low- and middle-income countries (LMICs)


Received: 24 August 2020; Accepted: 07 September 2020; Published: 25 December 2020.

doi: 10.21037/jphe-2020-gs-08


Introduction

Global child health is incomplete without the whole-hearted inclusion of children’s surgery. An estimated 1.7 billion children do not have access to safe, timely, and affordable surgery and anesthesia care globally (1). In the least developed and low-income countries of the world, an estimated 40% of the population is comprised of children under the age of 15, with the proportion exceeding 50% in Niger (2).

According to the landmark report of the Lancet Commission on Global Surgery (LCoGS), 143 million additional surgical procedures are needed in LMICs in order to avert life-long disability and death (3). However, data on unmet surgical need (USN) specific to children’s surgery remain fragmented. Smith et al. reported that the national proportion of pediatric USN in Uganda was 6.9%, with the proportion of USN being higher in children under the age of 5 (4). In addition, Butler and colleagues examined the USN in four low-income countries and noted that 19% of children had a surgical need, of which 62% had at least one unmet need (5). Perhaps not surprisingly, low-income countries experience a shockingly high infant mortality rate of 50 per 1,000 live births compared with 5 per 1,000 live births in high-income countries (2). Additionally, neonatal disorders contribute to 8% of disability-adjusted life years (DALYs) and congenital anomalies and perinatal conditions are responsible for 13% of surgical DALYs worldwide (6).

Surgical care has a critical role to play in preventing morbidity and mortality, protecting patients and families against impoverishing expenditures, and achieving the United Nations’ Sustainable Development Goals (SDGs) (1,7-9). The third SDG (SDG-3) aims to end preventable deaths of newborns and children under 5 years of age and to reduce neonatal mortality to at least as low as 12 per 1,000 live births and under-5 mortality to at least as low as 25 per 1,000 live births by 2030 (10). There is strong evidence to suggest that among children above age 5 years, injuries lead to more deaths than HIV, malaria, and tuberculosis combined (11). Furthermore, given that among the 6.2 million children and adolescents who died in 2018, most deaths were due to preventable causes, the crucial role of surgery and anesthesia care in combating neonatal and child mortality cannot be overlooked (10). Since 2015, several advances—including the LGoCS; Disease Control Priorities, Third Edition’s Volume on Essential Surgery; and the World Health Assembly’s Resolution 68.15—have been made to actively advocate for the provision of safe and affordable surgical care to everyone, regardless of where they were born or where they live (3,12). Unfortunately, the vast need for global children’s surgery remains relatively unexplored and understudied. In recent years, there has been a growing momentum in this field, but a lot of ground needs to be covered. Therefore, in this review article, we will discuss challenges and achievements in global children’s surgery with a focus on workforce capacity, training and education, research, and financing (Table 1). We use the term “global children’s surgery” instead of global pediatric surgery to encompass all sub-specialties of surgery that cater to children’s needs.

Table 1
Table 1 Challenges and achievements in global children’s surgery
Full table

Workforce capacity

There continues to be a wide disparity in the demand and supply of children’s surgeons worldwide. Interestingly, in a global comparison of the pediatric surgery workforce capacity and training requirements, Lalchandani and Dunn noted that the number of pediatric surgeons per million children was inversely related to a country’s birth rate, with the highest birth rate but the lowest pediatric surgical workforce density (PSWD) noted in Ghana (13). However, there was a positive correlation between the number of pediatric surgeons and the gross domestic product (GDP) per capita in countries with GDP per capita less than US $20,000 (13). The number of pediatric surgeons per million children ranged from 0.51 to 29.30 among the 15 high- and low-middle income countries that they examined (13). Many African and South Asian countries seem to be affected more profoundly by these gross disparities than other nations (14). For example, Malawi has only 0.17 children’s surgeons per million children (15). Similarly, Pakistan has a children’s surgeon density of 0.4 per million children (16). These data reiterate that children living in some of the poorest and most resource-limited regions of the world have the highest need for surgical care, yet the lowest workforce capacity to receive this care.

In addition to alleviating the burden of USN, the provision of surgical care is also linked to outcomes. Using a novel approach, Hamad et al. defined the critical PSWD to improve surgical outcomes globally. They reported that a survival of 80% or more in their case series was significantly associated with a PSWD of at least 4 pediatric surgeons per million children under 15 years of age (OR 16.8, P<0.0001, 95% CI: 5.66–49.88) (17). Children’s surgery is a complex field with multiple subspecialties, which require specialized training and in-depth knowledge of anatomy, physiology, pharmacology, and pathology. It is important to acknowledge that children are not just “small adults” and that they have unique peri-operative care needs. Armed with this knowledge, an examination of the children’s surgical workforce in addition to surgeons reveals that there are severe workforce shortages in children’s anesthesia and nursing care as well (18-21). Dubowitz and colleagues reported that the per-capita anesthesia provider ratio in LMICs was often 100 times lower than in HICs (22). Additionally, the World Health Organization’s global surgery database indicates that among the estimated 550,000 specialist anesthesiologists worldwide, only 12% practice in Africa and southeast Asia, where one-third of the world’s population lives (23). It follows that anesthesiologists specialized in care of children, and specially neonates, are even rarer.

A multitude of factors have been attributed to the current workforce deficiencies in LMICs. Particularly, a lack of adequate training programs, emigration of specialists to other countries, inequitable distribution of resources within countries, and a loss of motivation on the part of the involved surgical care providers and other stakeholders are some of the cited reasons (24,25). In a survey from six Sub-Saharan African countries, Burch et al. noted that better financial and educational opportunities, access to latest technology and equipment, and improved living and working environment were some of the reasons which prompted medical students to pursue further training outside of Africa (26).


Training and education

The availability of robust training programs and educational opportunities has been linked to the availability of specialist children’s surgical care providers, which in turn leads to improved access to surgical and anesthesia care for children. In their case study of Uganda, Ozgediz and colleagues reported that most of the emergency surgical care is provided at first-level hospitals by medical and anesthesia officers, who have not received specialist surgical or anesthesia residency or fellowship training (27). Many resource-limited countries and regions in the world do not have an adequate number of medical schools and pediatric surgery residency or fellowship training programs (3). Furthermore, among the schools and programs that do exist, most are situated in urban areas, which adds barriers for children in rural areas to access care and for students, trainees and providers to receive optimal exposure to a variety of disease presentations and management approaches (24). A dearth of training opportunities is not the only challenge. More recently, a decline in medical students’ and graduates’ interest in pursuing surgery have also been noted (28-30). Data on factors affecting the selection of pediatric or children’s surgery as a career choice remain limited. In a single-country survey from Saudi Arabia, Alshahrani and colleagues noted that among more than 300 medical students and interns, none of the participants selected pediatric surgery as their specialty of choice (31). Further studies to better understand the choice of specialty and the factors influencing that decision in different parts of the world are warranted, but it is safe to suggest that the availability of strong mentorship significantly impacts a student or trainee’s decision to pursue a surgical career. In this context, there is mounting evidence which underscores the importance of mentorship throughout a surgeon’s life (32-34). Individuals who receive mentorship have been seen to achieve their goals earlier and experience greater career satisfaction (33). Given the low density of pediatric surgeons worldwide, especially in LMICs, many students and trainees may feel discouraged or lost when thinking about pursuing children’s surgery or may decide to pursue specialist training outside their country (26). These factors may explain why 98 out of the 168 pediatric surgery spots in Brazil went unfilled according to a 2009 survey (35). In a separate study, Chirdan et al. noted that 24.4% of African pediatric surgeons received their primary training outside of Africa, in Europe or North America. Moreover, a majority (52%) of pediatric surgical programs had only one or two trainees per training session, and 45% had no or irregular trainees (15). These data emphasize the need to strengthen local pediatric surgery training programs within LMICs and in addition, to establish sustainable international training and exchange opportunities to complement existing training programs.


Research

Responsibly conducted research has the potential to improve clinical practice, establish mutually beneficial collaborations, inform health policy, and enhance training opportunities. Research collaborations among colleagues from all over the world, including high-, middle-, and low-income countries have resulted in the publication of high-quality and impactful evidence in global health and global surgery. However, literature states that a certain level of inequity exists in global surgery research (36). In 2014, Elobu and colleagues conducted a survey among 43 Ugandan trainees to ascertain their perceptions of international collaborations. Only 15% of the trainees felt that the research conducted by the international or visiting groups aligned with Uganda’s national interest and even though 28% of respondents did participate in one or more such research activities, none of them were given authorship in the subsequent publications (37). In another study by Elobu et al., an overwhelming majority (n=33, 94%) of Ugandan anesthesia and surgery trainees reported that research was important to their career development and 85% wanted to publish their dissertation (38). However, most trainees considered their dissertations to be a financial burden, given that among the 81% who were receiving a scholarship, only 35% covered research costs (38). In addition to individual- or trainee-level factors that act as barriers to conducting high-quality research in global children’s surgery, a multitude of system-level factors have also been implicated in hindering progress. Since the publication of the LGoCS report, impressive strides have been made in the collection of baseline surgery, anesthesia and obstetrics data on access to timely surgery, perioperative mortality rates, and other indicators for adults (39,40). However, there have been very few global studies focused on determining metrics or indicators specifically for children’s surgery (1,4,5,17,41). Numerous gaps in the global surgery community’s knowledge about the accurate burden of surgical disease among children, peri-operative outcomes, backlog, cost-effectiveness, and LGoCS indicators still exist. Concerted efforts at the patient-, provider-, community-, government-, and international organization-level are required to answer these essential questions.


Financing

The systematic review conducted by Chao and colleagues played a pivotal role in dispelling the myth that “surgery is too expensive” (42). They noted that the median cost-effectiveness ratios of cleft lip or palate repair ($47.74 per DALY), general surgery ($82.32 per DALY), hydrocephalus surgery ($108.74 per DALY), and ophthalmic surgery ($136 per DALY) were similar to that of the BCG vaccine ($51.86–220.39 per DALY) (42). In addition, they concluded that many of the essential surgical procedures were very cost-effective in resource-limited countries. Building on that, Saxton et al. conducted an economic analysis of children’s surgical procedures in LMICs. The findings from this review suggested that nine pediatric surgical intervention categories provided a median economic benefit of greater than $10,000 per procedure (43). The authors calculated societal economic benefit gained from surgical care using a human capital approach, which equates the value of a human life to the discounted market value of the economic output produced by an individual over an expected lifetime. These data re-emphasize that surgery is one of the most cost-effective interventions in global health, affording a 1:10 cost-benefit ratio (44). Despite the substantial evidence on the cost-effectiveness of global children’s surgery, progress remains limited. There is an absence of comprehensive children’s surgical care models for LMICs to implement. In many LMICs, payment for surgery is out-of-pocket. Saing reported that among 14 Asian countries, 12 had self-payment procedures in place for surgery, and only 9 had an additional health insurance provision (45). Additionally, government-subsidized surgical care was available in almost all countries; however, it is difficult to ascertain whether the quality and level of care is at par with private healthcare institutions (45).


Achievements

Despite the aforementioned challenges and deficiencies within global children’s surgery, the community has achieved multiple major milestones in its efforts to improve access to safe surgical and anesthesia care for children. Concerted efforts are being made to bolster the surgical and anesthesia workforce in global children’s surgery in LMICs. Short training courses aimed at enhancing theoretical knowledge and skills regarding common children’s surgical conditions are being conducted in Vietnam and India (46,47). In addition, a 20-year follow-up study of African surgeons trained via the Pan-African Academy of Christian Surgeons (PAACS) showed that all of these surgeons are still practising in Africa (48). A few international organizations have also taken the lead in addressing the severe workforce and infrastructure deficiencies that exist in children’s surgery. For example, KidsOR, a non-governmental organization based in Scotland, has been working to set-up operating rooms and peri-operative care units in some of the world’s most resource-limited regions (49). Currently, their efforts have resulted in more than 24,000 life-saving surgeries, with more than 400,000 DALYs averted and an economic benefit upwards of eight billion US dollars (49).

Major strides have also been made in the research realm of the global children’s surgical community. GlobalSurg and GlobalPaedSurg are multi-institutional, international collaborative efforts, which have brought together researchers, surgeons, anesthesiologists, nurses, and other healthcare providers with the single aim of understanding the current state of children’s surgery and improving outcomes (50,51). Furthermore, the introduction and development of the National Surgical, Obstetrics, And Anesthesia Plans (NSOAPs) has been a major achievement of the global surgery community. More recently, there has been an emphasis on the mandatory inclusion of children’s surgery-specific recommendations in the NSOAPs (52). Pakistan and Nigeria are among the first countries to actively incorporate children’s surgery within their NSOAP process (52).

Perhaps most important has been the Global Initiative for Children’s Surgery (GICS)—a consortium of healthcare providers passionately advocating and striving to ensure safe surgical care for children the world over. GICS has championed the inclusion of LMIC providers and colleagues, especially trainees in all of its efforts, from research, to advocacy, to training (53). GICS published the Optimal Resources for Children’s Surgical Care (OReCS) document which details resources required for providing optimal surgical care to all children, at all levels of hospital care (54,55). Currently, GICS has been working towards promoting local solutions, engaging local providers, forming multiple partnerships with institutions, organizations, healthcare providers, and other stakeholders, and taking the lead in creating a world where every child has access to safe and timely surgery.


Conclusions

The past five years have seen an increasing interest and investment in global surgery. Even though the momentum in global children’s surgery has historically remained slow, recent efforts have translated into big advances for the community. From workforce capacity, to training and education, research, and financing, much still needs to be accomplished. The challenges facing children’s surgical care providers and other relevant stakeholders may seem daunting, but recent achievements underscore the importance of prioritizing each and every child’s health. No child must be left behind; only then can we truly achieve SDG-3 and actively combat neonatal, child, and adolescent morbidity and mortality.


Acknowledgments

Funding: None.


Footnote

Provenance and Peer Review: This article was commissioned by the Guest Editor (Dominique Vervoort) for the series “Global Surgery” published in Journal of Public Health and Emergency. The article has undergone external peer review.

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form, available at: http://dx.doi.org/10.21037/jphe-2020-gs-08. The series “Global Surgery” was commissioned by the editorial office without any funding or sponsorship. Both authors have no other conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.


References

  1. Mullapudi B, Grabski D, Ameh E, et al. Estimates of number of children and adolescents without access to surgical care. Bull World Health Organ 2019;97:254-8. [Crossref] [PubMed]
  2. Kaneda T, Bietsch K. World Population Data Sheet (2015). Population Reference Bureau 2015. Available online: http://www.prb.org/pdf15/2015-world-population-data-sheet_eng.pdf%0Ahttp://www.jstor.org/stable/1972177?origin=crossref
  3. Meara JG, Leather AJM, Hagander L, et al. Global Surgery 2030: Evidence and solutions for achieving health, welfare, and economic development. Lancet 2015;386:569-624. [Crossref] [PubMed]
  4. Smith ER, Vissoci JRN, Rocha TAH, et al. Geospatial analysis of unmet pediatric surgical need in Uganda. J Pediatr Surg 2017;52:1691-8. [Crossref] [PubMed]
  5. Butler EK, Tran TM, Nagarajan N, et al. Epidemiology of pediatric surgical needs in low-income countries. PLoS One 2017;12:e0170968. [Crossref] [PubMed]
  6. Ologunde R, Maruthappu M, Shanmugarajah K, et al. Surgical care in low and middle-income countries: Burden and barriers. Int J Surg 2014;12:858-63. [Crossref] [PubMed]
  7. Beard JH, Ohene-Yeboah M, deVries CR, et al. Hernia and Hydrocele. In: Disease Control Priorities, Third Edition (Volume 1): Essential Surgery. The World Bank, 2015:151-71. Available online: https://www.ncbi.nlm.nih.gov/books/NBK333501/
  8. Owen RM, Capper B, Lavy C. Clubfoot treatment in 2015: A global perspective. BMJ Global Health 2018;3:e000852. [Crossref] [PubMed]
  9. Farmer D, Sitkin N, Lofberg K, et al. Surgical Interventions for Congenital Anomalies. In: Disease Control Priorities, Third Edition (Volume 1): Essential Surgery. The World Bank, 2015:129-49.
  10. Health - United Nations Sustainable Development. Available online: https://www.un.org/sustainabledevelopment/health/
  11. Colin Mathers TB and DMF. The global burden of disease 2004 update. Geneva: World Health Organization, 2008:146.
  12. Debas HT, Donkor P, Gawande A, et al. Disease Control Priorities, Third Edition (Volume 1): Essential Surgery. Disease Control Priorities, Third Edition (Volume 1): Essential Surgery. The World Bank, 2015. Available online: https://www.ncbi.nlm.nih.gov/books/NBK333500/
  13. Lalchandani P, Dunn JCY. Global comparison of pediatric surgery workforce and training. J Pediatr Surg 2015;50:1180-3. [Crossref] [PubMed]
  14. Krishnaswami S, Nwomeh BC, Ameh EA. The pediatric surgery workforce in low- and middle-income countries: Problems and priorities. Semin Pediatr Surg 2016;25:32-42. [Crossref] [PubMed]
  15. Chirdan LB, Ameh EA, Abantanga FA, et al. Challenges of training and delivery of pediatric surgical services in Africa. J Pediatr Surg 2010;45:610-8. [Crossref] [PubMed]
  16. Siddiqui S, Vervoort D, Peters AW, et al. Closing the gap of children’s surgery in Pakistan. World J Pediatr Surg 2019;2:e000027. [Crossref]
  17. Hamad D, Yousef Y, Caminsky NG, et al. Defining the critical pediatric surgical workforce density for improving surgical outcomes: a global study. J Pediatr Surg 2020;55:493-512. [Crossref] [PubMed]
  18. Vansell HJ, Schlesinger JJ, Harvey A, et al. Anaesthesia, surgery, obstetrics, and emergency care in Guyana. J Epidemiol Glob Health 2015;5:75-83. [Crossref] [PubMed]
  19. Ozgediz D, Kijjambu S, Galukande M, et al. Africa's neglected surgical workforce crisis. Lancet 2008;371:627-8. [Crossref] [PubMed]
  20. Hodges SC, Mijumbi C, Okello M, et al. Anaesthesia services in developing countries: Defining the problems. Anaesthesia 2007;62:4-11. [Crossref] [PubMed]
  21. Jochberger S, Ismailova F, Lederer W, et al. Anesthesia and its allied disciplines in the developing world: A nationwide survey of the Republic of Zambia. Anesth Analg 2008;106:942-8. [Crossref] [PubMed]
  22. Dubowitz G, Detlefs S, Kelly McQueen KA. Global anesthesia workforce crisis: A preliminary survey revealing shortages contributing to undesirable outcomes and unsafe practices. World J Surg 2010;34:438-44. [Crossref] [PubMed]
  23. Holmer H, Lantz A, Kunjumen T, et al. Global distribution of surgeons, anaesthesiologists, and obstetricians. Lancet Global Health 2015;3:S9-11. [Crossref] [PubMed]
  24. Krishnaswami S, Nwomeh BC, Ameh EA. The pediatric surgery workforce in low- and middle-income countries: Problems and priorities. Semin Pediatr Surg 2016;25:32-42. [Crossref] [PubMed]
  25. Gajewski J, Bijlmakers L, Mwapasa G, et al. ‘I think we are going to leave these cases’. Obstacles to surgery in rural Malawi: a qualitative study of provider perspectives. Trop Med Int Health 2018;23:1141-7. [Crossref] [PubMed]
  26. Burch VC, McKinley D, van Wyk J, et al. Career intentions of medical students trained in six Sub-Saharan African countries. Educ Health (Abingdon) 2011;24:614. [PubMed]
  27. Ozgediz D, Langer M, Kisa P, et al. Pediatric surgery as an essential component of global child health. Semin Pediatr Surg 2016;25:3-9. [Crossref] [PubMed]
  28. Chew YW, Rajakrishnan S, Low CA, et al. Medical students' choice of specialty and factors determining their choice: a cross-sectional questionnaire survey in Melaka-Manipal Medical College, Malaysia. Biosci Trends 2011;5:69-76. [Crossref] [PubMed]
  29. Deedar-Ali-Khawaja R, Khan SM. Trends of surgical career selection among medical students and graduates: A global perspective. J Surg Educ 2010;67:237-48. [Crossref] [PubMed]
  30. Bland KI, Isaacs G. Contemporary trends in student selection of medical specialties: The potential impact on general surgery. Arch Surg 2002;137:259-67. [Crossref] [PubMed]
  31. Alshahrani M, Dhafery B, Al Mulhim M, et al. Factors influencing Saudi medical students and interns' choice of future specialty: a self-administered questionnaire. Adv Med Educ Pract 2014;5:397-402. [Crossref] [PubMed]
  32. Farmer DL. Standing on the shoulders of giants: A scientific journey from Singapore to stem cells. J Pediatr Surg 2015;50:15-22. [Crossref] [PubMed]
  33. Sanfey H, Hollands C, Gantt NL. Strategies for building an effective mentoring relationship. Am J Surg 2013;206:714-8. [Crossref] [PubMed]
  34. Healy NA, Cantillon P, Malone C, et al. Role models and mentors in surgery. Am J Surg 2012;204:256-61. [Crossref] [PubMed]
  35. de Jesus LE, Aguiar AS. Needs and specialization for pediatric surgeons in Brazil. Rev Col Bras Cir 2009;36:356-61. [PubMed]
  36. Sgrò A, Al-Busaidi IS, Wells CI, et al. Global Surgery: A 30-Year Bibliometric Analysis (1987-2017). World J Surg 2019;43:2689-98. [Crossref] [PubMed]
  37. Elobu AE, Kintu A, Galukande M, et al. Evaluating international global health collaborations: Perspectives from surgery and anesthesia trainees in Uganda. Surgery 2014;155:585-92. [Crossref] [PubMed]
  38. Elobu AE, Kintu A, Galukande M, et al. Research in surgery and anesthesia: Challenges for post-graduate trainees in Uganda. Educ Health (Abingdon) 2015;28:11-5. [Crossref] [PubMed]
  39. Fatima I, Shoman H, Peters A, et al. Assessment of Pakistan’s Surgical System by Tracking Lancet Global Surgery Indicators Toward a National Surgical, Obstetric, and Anaesthesia Plan. J Am Coll Surg 2019;229:S125. [Crossref]
  40. Hanna JS, Herrera-Almario GE, Pinilla-Roncancio M, et al. Use of the six core surgical indicators from Lancet Commission on Global Surgery in Colombia: a situational analysis. Lancet Global Health 2020;8:e699-710. [Crossref] [PubMed]
  41. Poenaru D, Seyi-Olajide JO. Developing Metrics to Define Progress in Children’s Surgery. World J Surg 2019;43:1456-65. [Crossref] [PubMed]
  42. Chao TE, Sharma K, Mandigo M, et al. Cost-effectiveness of surgery and its policy implications for global health: A systematic review and analysis. Lancet Global Health 2014;2:e334-45. [Crossref] [PubMed]
  43. Saxton AT, Poenaru D, Ozgediz D, et al. Economic analysis of children’s surgical care in low- and middle-income countries: A systematic review and analysis. PLoS One 2016;11:e0165480. [Crossref] [PubMed]
  44. Surgery - Disease Control Priorities in Developing Countries - NCBI Bookshelf. Available online: https://www.ncbi.nlm.nih.gov/books/NBK11719/
  45. Saing H. Training and delivery of pediatric surgery services in Asia. Available online: https://pubmed.ncbi.nlm.nih.gov/11083433/
  46. Holterman AX. Deploying Pediatric Acute Surgical Support (PASS)-an interdisciplinary multimodal course for initial response to life-threatening pediatric surgical emergencies. Available online: https://pediatrics-neonatology-conferences.magnusgroup.org/program/scientific-program/deploying-pediatric-acute-surgical-support-pass-an-interdisciplinary-multimodal-course-for-initial-response-to-life-threatening-pediatric-surgical-emergencies
  47. Madhuri V, Stewart RJ, Lakhoo K. Training of children’s surgical teams at district level in low- and middle-income countries (LMIC). Available online: https://journals.lww.com/ijsgh/Fulltext/2019/10000/Training_of_children_s_surgical_teams_at_district.2.aspx
  48. Van Essen C, Steffes BC, Thelander K, et al. Increasing and Retaining African Surgeons Working in Rural Hospitals: An Analysis of PAACS Surgeons with Twenty-Year Program Follow-Up. World J Surg 2019;43:75-86. [Crossref] [PubMed]
  49. Research and Impact | KidsOR. Available online: https://www.kidsor.org/what-we-do/research-and-impact/
  50. About GlobalSurg - Globalsurg. Available online: https://globalsurg.org/who-we-are/
  51. About the Study - Global Paed Surg. Available online: http://globalpaedsurg.com/about-study/
  52. Peters AW, Roa L, Rwamasirabo E, Ameh E, et al. National surgical, obstetric, and anesthesia plans supporting the vision of universal health coverage. Vol. 8, Global Health Science and Practice. Johns Hopkins University Press, 2020. Available online: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108944/
  53. Global Initiative for Children’s Surgery. Global Initiative for Children’s Surgery: A Model of Global Collaboration to Advance the Surgical Care of Children. World J Surg 2019;43:1416-25. [Crossref] [PubMed]
  54. Goodman LF, St-Louis E, Yousef Y, et al. The Global Initiative for Children’s Surgery: Optimal Resources for Improving Care. Eur J Pediatr Surg 2018;28:51-9. [Crossref] [PubMed]
  55. Global Initiative for Children’s Surgery. Optimal Resources for Children’s Surgical Care: Executive Summary. World J Surg 2019;43:978-80. [Crossref] [PubMed]
doi: 10.21037/jphe-2020-gs-08
Cite this article as: Abbas A, Samad L. Children at the heart of global surgery: children’s surgery in low- and middle-income countries. J Public Health Emerg 2020;4:34.