Comparison of plasma lipids changes after middle-distance running in euglycemic and diabetic subjects

Giuseppe Lippi, Cantor Tarperi, Gian Luca Salvagno, Marco Benati, Elisa Danese, Martina Montagnana, Paolo Moghetti, Federico Schena


Background: Although regular performance of aerobic physical exercise is pivotal for preserving or improving health and fitness, scarce information is available on plasma lipids changes after middle-distance running in euglycemic and diabetic subjects.
Methods: Eleven male euglycemic amateur runners (mean age 41±6 years) and 9 male diabetic amateur runners (4 with type 1 and 5 with type 2 diabetes; mean age 55±14 years) participated to a 21.1-km running trial. All subjects belonged to an amateur running team, regularly engaged in amateur running. Blood was collected before the start of the trial and immediately after. The lipid profile, encompassing measurement of total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), was assayed with Roche Cobas 6000.
Results: All athletes successfully completed the 21.1-km running trial, with running pace comprised between 9.6–12.8 km/h. In both categories of subjects the values of LDL-C significantly decreased by approximately 6% after the run, whilst HDL-C and triglycerides significantly increased by 6–9% and 30–36%, respectively. The post-run variations of all lipoprotein fractions after the running trial were virtually identical in diabetic and euglycemic subjects.
Conclusions: The results of this study show for the first time that middle-distance running elicits acute favorable changes of lipid profile both in euglycemic and diabetic subjects. This form of endurance exercise shall hence be further fostered for purposes of public health promotion and improvement.