Article Abstract

Risk factors associated with TB, a case-control study in a Chinese population

Authors: Cheng Chen, Limei Zhu, Dandan Yang, Yan Shao, Song Honghuan, Guoli Li, Wei Lu


Background: Tuberculosis (TB) remains one of the leading communicable diseases in the world, and this case-control study was conducted to explore potential risk factors for TB.
Methods: A total of 104 new TB patients were collected in 2011, and each 2 cases were matched with one healthy control. A standardized questionnaire was applied for risk factors collection. Multivariate logistic regression analysis was employed for multi-factors analysis, and the association between related factors and TB risk were estimated by odds ratio (OR) and 95% confidence intervals (95% CI).
Results: Multivariate logistic regression showed that frequent fruits intake and physical activity, high body mass index (BMI) were associated with decreased risk of TB (OR =0.20, 95% CI: 0.08–0.53; OR =0.41, 95% CI: 0.17–1.00; OR =0.86, 95%CI: 0.76–0.97; respectively), while diabetes mellitus (DM) and no ventilation of working place were related to increased risk of TB (OR =12.99, 95% CI: 1.30–129.58; OR =3.39, 95% CI: 1.24–9.26; respectively).
Conclusions: Lower BMI might be susceptible to TB, and frequent fruits consumption and more physical activity would low the risk of TB. Meanwhile, ventilation of working place and DM treatment will be in the necessity for TB control.